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Cabazitaxel Injection

Why is this medication prescribed?
Cabazitaxel injection is used along with prednisone to treat prostate cancer (cancer of a male reproductive organ) that has already been treated with other medications. Cabazitaxel injection is in a class of medications called microtubule inhibitors. It works by slowing or stopping the growth of cancer cells.

How should this medication be used?
Cabazitaxel injection comes as a liquid to be given intravenously (into a vein) over 1 hour by a doctor or nurse in a medical facility. It is usually given once every 3 weeks.

You will need to take prednisone every day during your treatment with cabazitaxel injection. It is important that you take prednisone exactly as prescribed by your doctor. Tell your doctor if you have missed doses or have not taken prednisone as prescribed.

Your doctor may need to stop or delay your treatment or decrease your dose if you experience certain severe side effects. Be sure to tell your doctor how you are feeling during your treatment.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Are there other uses for this medicine?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Other names
Jevtana®

What special precautions should I follow?

Before receiving cabazitaxel injection,


tell your doctor and pharmacist if you are allergic to cabazitaxel injection, any other medications, polysorbate 80, or any of the other ingredients in cabazitaxel injection. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: antifungals such as ketoconazole (Nizoral), itraconazole (Sporanox), and voriconazole (Vfend); clarithromycin (Biaxin); certain medications for human immunodeficiency virus (HIV) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); certain medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), and phenobarbital; nefazodone; rifabutin (Mycobutin), rifapentin (Priftin); rifampin (Rimactin, in Rifamate, in Rifater); and telithromycin (Ketek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with cabazitaxel injection, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor what herbal products you are taking, especially St. John's wort.
tell your doctor if you have or have ever had liver or kidney disease.
you should know that cabazitaxel injection is usually used in men with prostate cancer. If used by pregnant women, cabazitaxel injection can cause harm to the fetus. Women who are or may become pregnant or are breast-feeding should not receive cabazitaxel injection. If you receive cabazitaxel injection while you are pregnant, call your doctor. You should use birth control to prevent pregnancy during your treatment with cabazitaxel injection.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving cabazitaxel injection.
What special dietary instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.


What side effects can this medication cause?
Cabazitaxel injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

nausea
heartburn
constipation
stomach pain
change in ability to taste food
loss of appetite
weight loss
swelling of the inside of the mouth
headache
joint or back pain
numbness, burning, or tingling in the hands, arms, feet, or legs
hair loss

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

diarrhea
vomiting
swelling of the face, arms, hands, feet, ankles, or lower legs
decreased urination
blood in the urine
dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration
irregular heartbeat
shortness of breath
pale skin
tiredness or weakness
unusual bruising or bleeding

Cabazitaxel injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].

What should I do in case of overdose?
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include the following:

sore throat, cough, fever, chills, muscle aches, burning on urination, or other signs of infection
unusual bruising or bleeding
pale skin
shortness of breath
excessive tiredness or weakness
nausea
vomiting
diarrhea

What other information should I know?
Ask your pharmacist any questions you have about cabazitaxel injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


Important warning
Cabazitaxel injection may cause a serious or life-threatening decrease in the number of white blood cells (a type of blood cell that is needed to fight infection) in your blood. This increases the risk that you will develop a serious infection. Tell your doctor if you are 65 years of age or older, if you have or have ever had a low number of white blood cells along with a fever, if you have been treated with radiation therapy, and if you are unable to eat a healthy diet. Your doctor will order laboratory tests to check the number of white blood cells in your blood before and during your treatment. If you have a low number of white blood cells, your doctor may decrease your dose or stop or delay your treatment. Your doctor may also prescribe a medication to help prevent life-threatening complications if your white blood cells decrease. If you experience any of the following symptoms, call your doctor immediately: sore throat, fever (a temperature greater than 100.4°F), chills, muscle aches, cough, burning on urination, or other signs of infection.

Cabazitaxel injection may cause severe or life-threatening allergic reactions, especially when you receive your first two infusions of cabazitaxel injection. Your doctor will give you medications to prevent an allergic reaction at least 30 minutes before you receive cabazitaxel injection. You should receive your infusion in a medical facility where you can be treated quickly if you have a reaction. Tell your doctor if you are allergic to cabazitaxel injection or polysorbate 80 (an ingredient found in some foods and medications). Ask your doctor if you are not sure if a food or medication you are allergic to contains polysorbate 80. If you experience an allergic reaction to cabazitaxel injection, it may begin within a few minutes after your infusion starts, and you may experience the following symptoms: rash, reddening of the skin, itching, dizziness, faintness, or tightening of the throat. Tell your doctor or nurse right away if you experience any of these symptoms.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to cabazitaxel injection.

Talk to your doctor about the risks of taking cabazitaxel injection.

Prednisolone Ophthalmic (pred niss' oh lone)

Why is this medication prescribed?
Prednisolone reduces the irritation, redness, burning, and swelling of eye inflammation caused by chemicals, heat, radiation, infection, allergy, or foreign bodies in the eye. It sometimes is used after eye surgery.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medication be used?
Prednisolone comes as eyedrops and eye ointment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use prednisolone exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
If you are using the suspension form of prednisolone eyedrops (Pred Forte, Pred Mild, Econopred, Econopred Plus), shake the bottle well before each dose. It is not necessary to shake prednisolone eyedrop solution (AK-Pred, Inflamase Mild, Inflamase Forte).
Continue to use prednisolone even if you feel well. Do not stop using prednisolone without talking to your doctor.
To use the eyedrops, follow these instructions:
  1. Wash your hands thoroughly with soap and water.
  2. Use a mirror or have someone else put the drops in your eye.
  3. If using prednisolone suspension eyedrops, shake the bottle well for 10 seconds.
  4. Remove the protective cap. Make sure that the end of the dropper is not chipped or cracked.
  5. Avoid touching the dropper tip against your eye or anything else.
  6. Hold the dropper tip down at all times to prevent drops from flowing back into the bottle and contaminating the remaining contents.
  7. Lie down or tilt your head back.
  8. Holding the bottle between your thumb and index finger, place the dropper tip as near as possible to your eyelid without touching it.
  9. Brace the remaining fingers of that hand against your cheek or nose.
  10. With the index finger of your other hand, pull the lower lid of the eye down to form a pocket.
  11. Drop the prescribed number of drops into the pocket made by the lower lid and the eye. Placing drops on the surface of the eyeball can cause stinging.
  12. Close your eye and press lightly against the lower lid with your finger for 2 to 3 minutes to keep the medication in the eye. Do not blink.
  13. Replace and tighten the cap right away. Do not wipe or rinse it off.
  14. Wipe off any excess liquid from your cheek with a clean tissue. Wash your hands again.

To use the eye ointment, follow these instructions:
  1. Wash your hands thoroughly with soap and water.
  2. Use a mirror or have someone else apply the ointment.
  3. Avoid touching the tip of the tube against your eye or anything else. The ointment must be kept clean.
  4. Tilt your head forward slightly.
  5. Holding the tube between your thumb and index finger, place the tube as near as possible to your eyelid without touching it.
  6. Brace the remaining fingers of that hand against your cheek or nose.
  7. With the index finger of your other hand, pull the lower lid of your eye down to form a pocket.
  8. Place a small amount of ointment into the pocket made by the lower lid and the eye. A 1/2-inch (1.25-centimeter) strip of ointment usually is enough unless otherwise directed by your doctor.
  9. Gently close your eyes and keep them closed for 1 to 2 minutes to allow the medication to be absorbed.
  10. Replace and tighten the cap right away.
  11. Wipe off any excess ointment from your eyelids and lashes with a clean tissue. Wash your hands again.

  • AK-Cide® (as a combination product containing Prednisolone, Sulfacetamide)
  • AK-Pred®
  • Blephamide® (as a combination product containing Prednisolone, Sulfacetamide)
  • Cetapred® (as a combination product containing Prednisolone, Sulfacetamide)
  • Econopred®
  • Inflamase®
  • Isolone®
  • Isopto Cetapred® (as a combination product containing Prednisolone, Sulfacetamide)
  • Medasulf® (as a combination product containing Prednisolone, Sulfacetamide)
  • Metimyd® (as a combination product containing Prednisolone, Sulfacetamide)
  • Ocu-Pred®
  • Omnipred®
  • Optimyd® (as a combination product containing Prednisolone, Sulfacetamide)
  • Poly Pred® (as a combination product containing Neomycin, Polymyxin B, Prednisolone)
  • Pred Forte
  • Pred-G® (as a combination product containing Gentamicin Sulfate, Prednisolone)
  • Pred Mild
  • Prednisol®
  • Predsulfair® (as a combination product containing Prednisolone, Sulfacetamide)
  • Sulster® (as a combination product containing Prednisolone, Sulfacetamide)
  • Supred® (as a combination product containing Prednisolone, Sulfacetamide)
  • Vasocidin® (as a combination product containing Prednisolone, Sulfacetamide)
What special precautions should I follow?

Before using prednisolone eyedrops or eye ointment,

  • tell your doctor and pharmacist if you are allergic to prednisolone or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins.
  • tell your doctor if you have or have ever had glaucoma or diabetes.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using prednisolone, call your doctor immediately.
What side effects can this medication cause?
Prednisolone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • temporary eye burning or stinging
  • temporary blurred vision

If you experience the following symptom, call your doctor immediately:
  • eye pain

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
What should I do if I forget to take a dose?
Apply the missed dose as soon as you remember it. Use any remaining doses for that day at evenly spaced intervals. However, if you remember a missed dose at the time the next one is due, use only the regularly scheduled dose. Do not apply a double dose to make up for a missed one.
What storage conditions are needed for this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
What other information should I know?
Keep all appointments with your doctor.
Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
If you still have symptoms of eye irritation after you finish the prednisolone, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Econazole Topical (e kon' na zole)

Why is this medication prescribed?
Econazole is used to treat skin infections such as athlete's foot, jock itch, and ringworm.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medication be used?
Econazole comes as a cream to apply to the skin. Econazole is usually used once or twice a day, in the morning and evening, for 2 weeks. Some infections require up to 6 weeks of treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use econazole exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Thoroughly clean the infected area, allow it to dry, and then gently rub the medication in until most of it disappears. Use just enough medication to cover the affected area. You should wash your hands after applying the medication.
Continue to use econazole even if you feel well. Do not stop using econazole without talking to your doctor.
  • Spectazole®
What special precautions should I follow?

Before using econazole,

  • tell your doctor and pharmacist if you are allergic to econazole or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription drugs you are taking, including vitamins.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using econazole, call your doctor.

What side effects can this medication cause?
Econazole may cause side effects. If you experience any of the following symptoms, call your doctor immediately:
  • itching
  • burning
  • irritation
  • stinging
  • redness
  • rash

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
What should I do if I forget to take a dose?
Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.
What storage conditions are needed for this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
What other information should I know?
Keep all appointments with your doctor. Econazole is for external use only. Do not let econazole get into your eyes or mouth, and do not swallow it. Do not apply cosmetics, lotions, or other skin medications to the area being treated unless your doctor tells you.
Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription. If you still have symptoms of infection after you finish econazole, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Hydrocodone (hye droe koe' done)

Why is this medication prescribed?
Hydrocodone is available only in combination with other ingredients, and different combination products are prescribed for different uses. Some hydrocodone products are used to relieve moderate to severe pain. Other hydrocodone products are used to relieve cough. Hydrocodone is in a class of medications called opiate (narcotic) analgesics and in a class of medications called antitussives. Hydrocodone relieves pain by changing the way the brain and nervous system respond to pain. Hydrocodone relieves cough by decreasing activity in the part of the brain that causes coughing.
Hydrocodone must be used with caution in children. Extended-release products containing hydrocodone should not be given to children younger than 6 years of age and should be used with caution in children 6-12 years of age. Talk to your doctor about the risks of giving hydrocodone to your child.
You will take hydrocodone in combination with at least one other medication, but this monograph only provides information about hydrocodone. Be sure to read information about the other ingredients in the hydrocodone product you are taking. Ask your doctor or pharmacist if you have any questions.
How should this medication be used?
Hydrocodone comes as a tablet, a capsule, a syrup, a solution (clear liquid), an extended-release (long-acting) capsule, and an extended-release (long-acting) suspension (liquid) to take by mouth. The tablet, capsule, syrup, and solution are usually taken every 4-6 hours as needed. The extended-release capsule and the extended-release suspension are usually taken every 12 hours as needed. If you are taking hydrocodone on a regular schedule, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Swallow the extended-release capsules whole; do not split, chew, or crush them.
Shake the extended-release suspension well before each use to mix the medication evenly. Do not mix the extended-release suspension with other medications or with other liquids such as water.
If you will be using hydrocodone solution, syrup, or extended-release suspension, do not use a household teaspoon to measure your dose. Household teaspoons are not accurate measuring devices, and you may receive too much medication or not enough medication if you measure your dose with a household teaspoon. Instead, use a properly marked measuring device such as a dropper, medicine spoon, or oral syringe. Ask your doctor or pharmacist if you need help getting or using a measuring device.
Call your doctor if your symptoms are not controlled by the hydrocodone product you are taking. Do not increase your dose of medication on your own. You may receive a dangerous overdose if you take more medication or take your medication more often than prescribed by your doctor.
Hydrocodone may be habit-forming. Take hydrocodone exactly as directed. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor. Call your doctor if you develop a strong desire to take more medication than prescribed.
If you have taken hydrocodone for several weeks or longer, do not stop taking the medication without talking to your doctor. If you suddenly stop taking hydrocodone, you may experience withdrawal symptoms. Your doctor will probably decrease your dose gradually.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient, available for certain hydrocodone combination products.
Are there other uses for this medicine?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
  • A-G Tussin® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Allay® (as a combination product containing Acetaminophen, Hydrocodone)
  • Alor® (as a combination product containing Aspirin, Hydrocodone)
  • Ambi® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Amtussin® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Anaplex HD® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • Anexsia® (as a combination product containing Acetaminophen, Hydrocodone)
  • Anolor DH5® (as a combination product containing Acetaminophen, Hydrocodone)
  • Atuss EX® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Atuss G® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Atuss HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Atuss HS® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Atuss HX® (as a combination product containing Guaifenesin, Hydrocodone)
  • Atuss MR® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Atuss MS® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Azdone® (as a combination product containing Aspirin, Hydrocodone)
  • Baltussin HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Bancap HC® (as a combination product containing Acetaminophen, Hydrocodone)
  • Bromcomp® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • Bromph HD® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • Bromplex HD® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • Brovex HC® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • B-Tuss® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Canges HC® (as a combination product containing Brompheniramine, Hydrocodone, Phenylephrine)
  • Canges XP® (as a combination product containing Guaifenesin, Hydrocodone)
  • Ceta Plus® (as a combination product containing Acetaminophen, Hydrocodone)
  • Chemdal HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Chemdal HD Plus® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Chemtussin HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Chlorgest HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Chlorphen HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Cleartuss DH® (as a combination product containing Guaifenesin, Hydrocodone)
  • Codal DH® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Codiclear DH® (as a combination product containing Guaifenesin, Hydrocodone)
  • Codimal DH® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Codituss DH® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Codotuss® (as a combination product containing Guaifenesin, Hydrocodone)
  • Co-Gesic® (as a combination product containing Acetaminophen, Hydrocodone)
  • Coldcough XP® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Comtussin HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Condasin® (as a combination product containing Guaifenesin, Hydrocodone)
  • Cophene-X-P® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Cordron HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Cordron-HC NR® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Co-Tussin® (as a combination product containing Guaifenesin, Hydrocodone)
  • Cotuss-V® (as a combination product containing Guaifenesin, Hydrocodone)
  • Co-Tuss V Expectorant® (as a combination product containing Guaifenesin, Hydrocodone)
  • Crantex HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Cyndal HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Cytuss HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Cytuss-HC NR® (as a combination product containing Dexbrompheniramine, Hydrocodone, Phenylephrine)
  • Damason-P® (as a combination product containing Aspirin, Hydrocodone)
  • De-Chlor G® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • De-Chlor HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • De-Chlor HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • De-Chlor MR® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • De-Chlor NX® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Deconamine CX® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Decotuss-HD® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Detussin® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Detussin Expectorant® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Dicomal-DH® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Ditussin-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Dolacet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Dolagesic® (as a combination product containing Acetaminophen, Hydrocodone)
  • Dolorex Forte® (as a combination product containing Acetaminophen, Hydrocodone)
  • Donatussin DC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Donatussin MAX® (as a combination product containing Carbinoxamine, Hydrocodone, Phenylephrine)
  • Drituss HD® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Drocon-CS® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • Drotuss CP® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • D-Tann HC® (as a combination product containing Diphenhydramine, Hydrocodone, Phenylephrine)
  • DuoCet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Duradal HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Duradal HD Plus® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Duratuss HD® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Dynatuss DF® (as a combination product containing Guaifenesin, Hydrocodone)
  • Dynatuss HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Dynex HD® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Dytan-HC® (as a combination product containing Diphenhydramine, Hydrocodone, Phenylephrine)
  • Echotuss-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Ed-TLC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Ed-Tuss HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Efasin-HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Efasin-HD Plus® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Endacof HC® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • EndaCof-Plus® (as a combination product containing Dexchlorpheniramine, Hydrocodone, Phenylephrine)
  • Endacof XP® (as a combination product containing Guaifenesin, Hydrocodone)
  • Endagen-HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Endal-HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Endal-HD Plus® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Enditussin-HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Endotuss-HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Enplus-HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Entuss® (as a combination product containing Guaifenesin, Hydrocodone)
  • Entuss D® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Entuss-D JR® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Entuss-D Liquid® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Entuss Expectorant® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Excof® (as a combination product containing Carbinoxamine, Hydrocodone, Phenylephrine)
  • ExeClear® (as a combination product containing Guaifenesin, Hydrocodone)
  • Execof XP® (as a combination product containing Guaifenesin, Hydrocodone)
  • Exetuss HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Exo-Tuss® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Extendryl HC® (as a combination product containing Guaifenesin, Hydrocodone)
  • Fentuss Expectorant® (as a combination product containing Guaifenesin, Hydrocodone)
  • FluTuss HC® (as a combination product containing Brompheniramine, Hydrocodone, Phenylephrine)
  • Flutuss XP® (as a combination product containing Guaifenesin, Hydrocodone)
  • Genecof HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • GeneCof XP® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Genocidin Tuss® (as a combination product containing Guaifenesin, Hydrocodone)
  • Gentex HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Gestuss-HC® (as a combination product containing Diphenhydramine, Hydrocodone, Phenylephrine)
  • G-Tuss® (as a combination product containing Guaifenesin, Hydrocodone)
  • Gua HC® (as a combination product containing Guaifenesin, Hydrocodone)
  • Guiaphen HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Guiaplex HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • H-C Tussive® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • HC-Tussive-D® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • H C Tussive-NR® (as a combination product containing Dexbrompheniramine, Hydrocodone, Phenylephrine)
  • Hexatussin® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Highland HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Histex HC® (as a combination product containing Carbinoxamine, Hydrocodone, Pseudoephedrine)
  • Hist-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Histinex D® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Histinex HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Histinex PV® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Hist-Plus® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Histuss HC® (as a combination product containing Carbinoxamine, Hydrocodone, Pseudoephedrine)
  • Histussin D® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Histussin-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Hi-Tuss HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • H-Tuss-D Liquid® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Hycet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Hycodan® (as a combination product containing Homatropine, Hydrocodone)
  • Hyco-DH® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Hycomal DH® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Hycomed® (as a combination product containing Acetaminophen, Hydrocodone)
  • Hycomine Compound® (as a combination product containing Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Hyco-pap® (as a combination product containing Acetaminophen, Hydrocodone)
  • Hycosin Expectorant® (as a combination product containing Guaifenesin, Hydrocodone)
  • Hycotuss® (as a combination product containing Guaifenesin, Hydrocodone)
  • Hycotuss Expectorant® (as a combination product containing Guaifenesin, Hydrocodone)
  • Hydex PD® (as a combination product containing Dexchlorpheniramine, Hydrocodone, Phenylephrine)
  • Hydone Formula Liquid® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Hydrocet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Hydrocod-GF® (as a combination product containing Guaifenesin, Hydrocodone)
  • Hydrocodone CP® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Hydrocodone HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Hydrocof-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Hydro-DP® (as a combination product containing Diphenhydramine, Hydrocodone, Phenylephrine)
  • Hydrofed® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Hydrogesic® (as a combination product containing Acetaminophen, Hydrocodone)
  • Hydro GP® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Hydromet® (as a combination product containing Homatropine, Hydrocodone)
  • Hydromide® (as a combination product containing Homatropine, Hydrocodone)
  • Hydron CP® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Hydron EX® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Hydron KGS® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Hydron PCS® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Hydropane® (as a combination product containing Homatropine, Hydrocodone)
  • Hydro PC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Hydro-PC II® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Hydro-PC II Plus® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Hydrophene DH® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Hydro Pro® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Hydro Pro D® (as a combination product containing Guaiacolsulfonate, Hydrocodone, Pseudoephedrine)
  • Hydrotropine® (as a combination product containing Homatropine, Hydrocodone)
  • Hydrotuss® (as a combination product containing Guaifenesin, Hydrocodone)
  • Hydrotuss HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Hydrotussin HD® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Hydrotussin HG® (as a combination product containing Guaifenesin, Hydrocodone)
  • Hydro-Tuss XP® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Hy-KXP® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Hyphed® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Hy-Phen® (as a combination product containing Acetaminophen, Hydrocodone)
  • Hyphen-HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • HyTan® (as a combination product containing Chlorpheniramine, Hydrocodone)
  • Hytussin® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Hytussin Expectorant® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Ibudone® (as a combination product containing Hydrocodone, Ibuprofen)
  • Iodal HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Iotussin D Liquid® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Iotussin HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • JayCof-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • J-Tan D HC® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • KG-Dal HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • KG-Dal HD Plus® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • KGS HC® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • KG-Tuss HD® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • KG-Tussin® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Kwelcof® (as a combination product containing Guaifenesin, Hydrocodone)
  • Levall® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Liquicet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Liquicough HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Liqui-Tuss HD® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Liquitussin HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Lorcet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Lorcet HD® (as a combination product containing Acetaminophen, Hydrocodone)
  • Lorcet Plus® (as a combination product containing Acetaminophen, Hydrocodone)
  • Lortab® (as a combination product containing Acetaminophen, Hydrocodone)
  • Lortab ASA® (as a combination product containing Aspirin, Hydrocodone)
  • Lortuss HC® (as a combination product containing Hydrocodone, Phenylephrine)
  • Marcof Expectorant® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Margesic-H® (as a combination product containing Acetaminophen, Hydrocodone)
  • Max HC® (as a combination product containing Carbinoxamine, Hydrocodone, Phenylephrine)
  • Maxidone® (as a combination product containing Acetaminophen, Hydrocodone)
  • Maxi-Tuss HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Maxi Tuss HCG® (as a combination product containing Guaifenesin, Hydrocodone)
  • Maxi-Tuss HCX® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Maxi-Tuss SA® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • M-Clear® (as a combination product containing Guaifenesin, Hydrocodone)
  • Medcodin® (as a combination product containing Guaifenesin, Hydrocodone)
  • Med-Hist Expectorant® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Med-Hist-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Medipain® (as a combination product containing Acetaminophen, Hydrocodone)
  • Medtuss HD® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • M-End Liquid® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • M-End Max® (as a combination product containing Brompheniramine, Hydrocodone, Phenylephrine)
  • Mintex HC® (as a combination product containing Carbinoxamine, Hydrocodone, Pseudoephedrine)
  • Mintuss EX® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Mintuss G® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Mintuss HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Mintuss MR® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Mintuss MS® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Mintuss NX® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • MonteFlu HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Monte-G HC® (as a combination product containing Guaifenesin, Hydrocodone)
  • Nalex DH® (as a combination product containing Hydrocodone, Phenylephrine)
  • Nalex Expectorant® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Narcof® (as a combination product containing Guaifenesin, Hydrocodone)
  • Nariz HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Nasatuss® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Nazarin HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Neo-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Norco® (as a combination product containing Acetaminophen, Hydrocodone)
  • Notuss® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Notuss-Forte® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Notuss PD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Novasus® (as a combination product containing Chlorpheniramine, Hydrocodone)
  • Oncet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Panacet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Panasal® (as a combination product containing Aspirin, Hydrocodone)
  • Pancof HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Pancof HC® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Pancof XP® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Panlor® (as a combination product containing Acetaminophen, Hydrocodone)
  • Pediatex HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Phena-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine, Pyrilamine)
  • PhendaCof HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • PhendaCof Plus® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Phendal-HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Pneumotussin® (as a combination product containing Guaifenesin, Hydrocodone)
  • Polygesic® (as a combination product containing Acetaminophen, Hydrocodone)
  • Poly Hist HC® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Poly-Tussin® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Poly Tussin XP® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Procet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Pro Clear® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Procof® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Procof D® (as a combination product containing Guaiacolsulfonate, Hydrocodone, Pseudoephedrine)
  • Prolex DH® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Propatuss Expectorant® (as a combination product containing Guaifenesin, Hydrocodone)
  • Pro Red® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Protex® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Protex D® (as a combination product containing Guaiacolsulfonate, Hydrocodone, Pseudoephedrine)
  • Protuss® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • Protuss D® (as a combination product containing Guaiacolsulfonate, Hydrocodone, Pseudoephedrine)
  • Pseudatex HC® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • P Tuss® (as a combination product containing Guaiacolsulfonate, Hydrocodone)
  • P-V-Tussin® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • P-V-Tussin Syrup® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Quala HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Qual-Tussin DC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Quindal HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Quindal HD Plus® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Q-V Tussin® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Relacon-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Relacon-HC NR® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Relasin HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Relasin-HCX® (as a combination product containing Guaifenesin, Hydrocodone)
  • Reprexain® (as a combination product containing Hydrocodone, Ibuprofen)
  • Rhinacon DH® (as a combination product containing Hydrocodone, Phenylephrine)
  • Rindal-HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Rindal HD Plus® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Rindal HPD® (as a combination product containing Diphenhydramine, Hydrocodone, Phenylephrine)
  • Simuc-HD® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Spantuss HD® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • SRC Expectorant® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Stagesic® (as a combination product containing Acetaminophen, Hydrocodone)
  • S-T Forte 2® (as a combination product containing Chlorpheniramine, Hydrocodone)
  • Su-Tuss HD® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • SymTan® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • SymTan A® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • T-Gesic® (as a combination product containing Acetaminophen, Hydrocodone)
  • Touro HC® (as a combination product containing Guaifenesin, Hydrocodone)
  • Triant-HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Trimal DH® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Tri Vent HC® (as a combination product containing Carbinoxamine, Hydrocodone, Pseudoephedrine)
  • Tusana D® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Tusdec HC® (as a combination product containing Hydrocodone, Phenylephrine)
  • Tusnel HC® (as a combination product containing Brompheniramine, Guaifenesin, Hydrocodone)
  • Tussadur-HD® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Tussafed-HC® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Tussafed-HCG® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Tussafin® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Tussafin Liquid® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Tuss AX® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Tuss-DS® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Tussend® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Tussend Expectorant® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Tussgen® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Tussgen Expectorant® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Tuss HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • TussiCaps® (as a combination product containing Chlorpheniramine, Hydrocodone)
  • Tussiclear DH® (as a combination product containing Guaifenesin, Hydrocodone)
  • Tussigon® (as a combination product containing Homatropine, Hydrocodone)
  • Tussinate® (as a combination product containing Diphenhydramine, Hydrocodone, Phenylephrine)
  • Tussin V® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Tussionex® (as a combination product containing Chlorpheniramine, Hydrocodone)
  • Tussive HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Tusso DF® (as a combination product containing Guaifenesin, Hydrocodone)
  • Tusso HC® (as a combination product containing Guaifenesin, Hydrocodone)
  • Tuss-PD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Tussplex® (as a combination product containing Hydrocodone, Phenylephrine, Pyrilamine)
  • Tuss S® (as a combination product containing Hydrocodone, Pseudoephedrine)
  • Tyrodone Expectorant® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Ugesic® (as a combination product containing Acetaminophen, Hydrocodone)
  • Uni-Lev® (as a combination product containing Guaifenesin, Hydrocodone, Phenylephrine)
  • Uni-Tricof HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Uni Tuss HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Vanacet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Vanacon® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Vanex Expectorant® (as a combination product containing Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Vanex-HD® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Vazotuss HC® (as a combination product containing Brompheniramine, Hydrocodone, Phenylephrine)
  • Vendone® (as a combination product containing Acetaminophen, Hydrocodone)
  • Ventuss® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Vicoclear DH® (as a combination product containing Guaifenesin, Hydrocodone)
  • Vicodin® (as a combination product containing Acetaminophen, Hydrocodone)
  • Vicodin Tuss® (as a combination product containing Guaifenesin, Hydrocodone)
  • Vicoprofen® (as a combination product containing Hydrocodone, Ibuprofen)
  • Vicotuss® (as a combination product containing Guaifenesin, Hydrocodone)
  • Vidone® (as a combination product containing Acetaminophen, Hydrocodone)
  • Vi Q Tuss® (as a combination product containing Guaifenesin, Hydrocodone)
  • Visvex HC® (as a combination product containing Brompheniramine, Hydrocodone, Pseudoephedrine)
  • Vitussin® (as a combination product containing Guaifenesin, Hydrocodone)
  • Vitussin Expectorant® (as a combination product containing Guaifenesin, Hydrocodone)
  • Vortex® (as a combination product containing Guaifenesin, Hydrocodone)
  • Welltuss HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Xodol® (as a combination product containing Acetaminophen, Hydrocodone)
  • XPECT HC® (as a combination product containing Guaifenesin, Hydrocodone)
  • Zamicet® (as a combination product containing Acetaminophen, Hydrocodone)
  • Z-Cof HC® (as a combination product containing Chlorpheniramine, Hydrocodone, Phenylephrine)
  • Z-Cof HCX® (as a combination product containing Guaifenesin, Hydrocodone)
  • ZHist® (as a combination product containing Chlorpheniramine, Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Zotex HC® (as a combination product containing Dexchlorpheniramine, Hydrocodone, Phenylephrine)
  • ZTuss® (as a combination product containing Chlorpheniramine, Guaifenesin, Hydrocodone, Pseudoephedrine)
  • Zydone® (as a combination product containing Acetaminophen, Hydrocodone)
  • Zymine HC® (as a combination product containing Hydrocodone, Pseudoephedrine, Triprolidine)
What special precautions should I follow?

Before taking hydrocodone,

  • tell your doctor and pharmacist if you are allergic to hydrocodone, the other medication in the hydrocodone combination product you are taking, other opiate (narcotic) medications such as morphine or codeine, or any other medications.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; antihistamines; antipsychotics (medications for mental illness); ipratropium (Atrovent); medications for irritable bowel disease, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems; monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have recently had surgery and if you have or have ever had lung disease; breathing problems; croup (a barking cough that most often occurs at night); a head injury; any condition that causes increased pressure in your brain; prostatic hypertrophy (enlargement of a male reproductive gland); urethral stricture (narrowing of the tube that removes urine from the body); Addison's disease (condition in which the body does not make enough of certain natural substances); glaucoma; or thyroid, intestinal, liver, or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking hydrocodone, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking hydrocodone.
  • you should know that hydrocodone may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
  • ask your doctor about the safe use of alcoholic beverages while you are taking hydrocodone. Alcohol can make the side effects from hydrocodone worse.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?
Hydrocodone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • nausea
  • vomiting
  • constipation
  • drowsiness
  • dizziness
  • lightheadedness
  • fuzzy thinking
  • anxiety
  • abnormally happy or abnormally sad mood
  • dry throat
  • difficulty urinating
  • rash
  • itching
  • narrowing of the pupils (black circles in the center of the eyes)

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
  • slowed or irregular breathing
  • chest tightness

Hydrocodone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
What should I do if I forget to take a dose?
This medication is usually taken as needed. If your doctor has told you to take hydrocodone regularly, take the missed dose as soon as you remember it. Then wait at least 4 hours before taking your next dose of the tablets, syrup, capsule, or solution, or at least 12 hours before taking your next dose of the extended-release capsules or extended-release solution. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What should I do in case of overdose?
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
  • narrowed or widened pupils
  • slow, shallow, or stopped breathing
  • slowed or stopped heartbeat
  • cold, clammy, or blue skin
  • excessive sleepiness
  • loss of consciousness
  • seizures
  • death

What storage conditions are needed for this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
Store hydrocodone in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets or capsules or how much liquid is left so you will know if any medication is missing.
What other information should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Hydrocodone is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Aspirin (as' pir in)

Why is this medication prescribed?
Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, colds, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots.
Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph only includes information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information.
How should this medication be used?
Prescription aspirin comes as an extended-release tablet (tablet that releases medication slowly over a period of time). Nonprescription aspirin comes as a regular tablet, an enteric-coated, delayed-release tablet (tablet that first begins to release medication some time after it is taken), a chewable tablet, powder, and a gum to take by mouth and a suppository to use rectally. Prescription aspirin is usually taken two or more times a day. Nonprescription aspirin is usually taken once a day to lower the risk of a heart attack or stroke. Nonprescription aspirin is usually taken every 4 to 6 hours as needed to treat fever or pain. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take aspirin exactly as directed. Do not take more or less of it or take it more often than directed by the package label or prescribed by your doctor.
Swallow the extended-release tablets whole with a full glass of water. Do not break, crush, or chew them.
Swallow the tablets with a full glass of water.
Chewable aspirin tablets may be chewed, crushed, or swallowed whole. Drink a full glass of water, immediately after taking these tablets.
Ask a doctor before you give aspirin to your child or teenager. Aspirin may cause Reye's syndrome (a serious condition in which fat builds up on the brain, liver, and other body organs) in children and teenagers, especially if they have a virus such as chicken pox or the flu.
If you have had oral surgery or surgery to remove your tonsils in the last 7 days, talk to your doctor about which types of aspirin are safe for you.
Delayed-release tablets begin to work some time after they are taken. Do not take delayed-release tablets for fever or pain that must be relieved quickly.
Stop taking aspirin and call your doctor if your fever lasts longer than 3 days, if your pain lasts longer than 10 days, or if the part of your body that was painful becomes red or swollen. You may have a condition that must be treated by a doctor.
To insert an aspirin suppository into the rectum, follow these steps:
  1. Remove the wrapper.
  2. Dip the tip of the suppository in water.
  3. Lie down on your left side and raise your right knee to your chest. (If you are left-handed, lie on your right side and raise your left knee.)
  4. Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in infants and children and 1 inch (2.5 centimeters) in adults. Hold it in place for a few moments.
  5. Do not stand up for at least 15 minutes. Then wash your hands thoroughly and resume your normal activities.

Are there other uses for this medicine?
Aspirin is also sometimes used to treat rheumatic fever (a serious condition that may develop after a strep throat infection and may cause swelling of the heart valves) and Kawasaki disease (an illness that may cause heart problems in children). Aspirin is also sometimes used to lower the risk of blood clots in patients who have artificial heart valves or certain other heart conditions and to prevent certain complications of pregnancy.
  • Acuprin®
  • Alka-Seltzer® (as a combination product containing Aspirin, Citric Acid, Sodium Bicarbonate)
  • Alka-Seltzer® Extra Strength (as a combination product containing Aspirin, Citric Acid, Sodium Bicarbonate)
  • Alka-Seltzer® Morning Relief (as a combination product containing Aspirin, Caffeine)
  • Alka-Seltzer® Plus Flu (as a combination product containing Aspirin, Chlorpheniramine, Dextromethorphan)
  • Alka-Seltzer® PM (as a combination product containing Aspirin, Diphenhydramine)
  • Alor® (as a combination product containing Aspirin, Hydrocodone)
  • Anacin® (as a combination product containing Aspirin, Caffeine)
  • Anacin® Advanced Headache Formula (as a combination product containing Acetaminophen, Aspirin, Caffeine)
  • Anacin® Aspirin Regimen
  • Ascriptin®
  • Aspergum®
  • Aspidrox®
  • Aspircaf® (as a combination product containing Aspirin, Caffeine)
  • Aspir-Mox®
  • Aspirtab®
  • Aspir-trin®
  • Axotal® (as a combination product containing Aspirin, Butalbital)
  • Azdone® (as a combination product containing Aspirin, Hydrocodone)
  • Bayer® Aspirin
  • Bayer® Aspirin Plus Calcium (as a combination product containing Aspirin, Calcium Carbonate)
  • Bayer® Aspirin PM (as a combination product containing Aspirin, Diphenhydramine)
  • Bayer® Back and Body Pain (as a combination product containing Aspirin, Caffeine)
  • BC Headache (as a combination product containing Aspirin, Caffeine, Salicylamide)
  • BC Powder (as a combination product containing Aspirin, Caffeine, Salicylamide)
  • Bufferin®
  • Buffex®
  • Damason-P® (as a combination product containing Aspirin, Hydrocodone)
  • Easprin®
  • Ecotrin®
  • Emagrin® (as a combination product containing Aspirin, Caffeine, Salicylamide)
  • Empirin®
  • Endodan® (as a combination product containing Aspirin, Oxycodone)
  • Entaprin®
  • Entercote®
  • Equagesic® (as a combination product containing Aspirin, Meprobamate)
  • Excedrin® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
  • Excedrin® Back & Body (as a combination product containing Acetaminophen, Aspirin)
  • Fasprin®
  • Genacote®
  • Gennin-FC®
  • Genprin®
  • Goody's® Body Pain (as a combination product containing Acetaminophen, Aspirin)
  • Halfprin®
  • Levacet® (as a combination product containing Acetaminophen, Aspirin, Caffeine, Salicylamide)
  • Lortab ASA® (as a combination product containing Aspirin, Hydrocodone)
  • Magnaprin®
  • Micrainin® (as a combination product containing Aspirin, Meprobamate)
  • Miniprin®
  • Minitabs®
  • Momentum® (as a combination product containing Aspirin, Phenyltoloxamine)
  • Norgesic® (as a combination product containing Aspirin, Caffeine, Orphenadrine)
  • Orphengesic® (as a combination product containing Aspirin, Caffeine, Orphenadrine)
  • Panasal® (as a combination product containing Aspirin, Hydrocodone)
  • Percodan® (as a combination product containing Aspirin, Oxycodone)
  • Ridiprin®
  • Robaxisal® (as a combination product containing Aspirin, Methocarbamol)
  • Roxiprin® (as a combination product containing Aspirin, Oxycodone)
  • Saleto® (as a combination product containing Acetaminophen, Aspirin, Caffeine, Salicylamide)
  • Sloprin®
  • Soma® Compound (as a combination product containing Aspirin, Carisoprodol)
  • Soma® Compound with Codeine (as a combination product containing Aspirin, Carisoprodol, Codeine)
  • Supac® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
  • Synalgos-DC® (as a combination product containing Aspirin, Caffeine, Dihydrocodeine)
  • Talwin® Compound (as a combination product containing Aspirin, Pentazocine)
  • Uni-Buff®
  • Uni-Tren®
  • Valomag®
  • Vanquish® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
  • Zorprin®
What special precautions should I follow?

Before taking aspirin,

  • tell your doctor and pharmacist if you are allergic to aspirin, other medications for pain or fever, tartrazine dye, or any other medications.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acetazolamide (Diamox); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); anticoagulants ('blood thinners') such as warfarin (Coumadin) and heparin; beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); diuretics ('water pills'); medications for diabetes or arthritis; medications for gout such as probenecid and sulfinpyrazone (Anturane); methotrexate (Trexall); other nonsteroidal anti-inflammatory drugs (NSAIDs) such as naproxen (Aleve, Naprosyn); phenytoin (Dilantin); and valproic acid (Depakene, Depakote). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
  • if you are taking aspirin on a regular basis to prevent heart attack or stroke, do not take ibuprofen (Advil, Motrin) to treat pain or fever without talking to your doctor. Your doctor will probably tell you to allow some time to pass between taking your daily dose of aspirin and taking a dose of ibuprofen.
  • tell your doctor if you have or have ever had asthma, frequent stuffed or runny nose, or nasal polyps (growths on the linings of the nose). If you have these conditions, there is a risk that you will have an allergic reaction to aspirin. Your doctor may tell you that you should not take aspirin.
  • tell your doctor if you often have heartburn, upset stomach, or stomach pain and if you have or have ever had ulcers, anemia, bleeding problems such as hemophilia, or kidney or liver disease.
  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breast-feeding. If you become pregnant while taking aspirin, call your doctor. Aspirin may harm the fetus and cause problems with delivery if it is taken during the last few months of pregnancy.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking aspirin.
  • if you drink three or more alcoholic drinks every day, ask your doctor if you should take aspirin or other medications for pain and fever.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?
Aspirin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • nausea
  • vomiting
  • stomach pain
  • heartburn

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
  • hives
  • rash
  • swelling of the eyes, face, lips, tongue, or throat
  • wheezing or difficulty breathing
  • hoarseness
  • fast heartbeat
  • fast breathing
  • cold, clammy skin
  • ringing in the ears
  • loss of hearing
  • bloody vomit
  • vomit that looks like coffee grounds
  • bright red blood in stools
  • black or tarry stools

Aspirin may cause other side effects. Call your doctor if you experience any unusual problems while you are taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
What should I do if I forget to take a dose?
If your doctor has told you to take aspirin on a regular basis and you miss a dose, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What should I do in case of overdose?
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
  • burning pain in the throat or stomach
  • vomiting
  • decreased urination
  • fever
  • restlessness
  • irritability
  • talking a lot and saying things that do not make sense
  • fear or nervousness
  • dizziness
  • double vision
  • uncontrollable shaking of a part of the body
  • confusion
  • abnormally excited mood
  • hallucination (seeing things or hearing voices that are not there)
  • seizures
  • drowsiness
  • loss of consciousness for a period of time

What storage conditions are needed for this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Store aspirin suppositories in a cool place or in a refrigerator. Throw away any medication that is outdated or no longer needed and any tablets that have a strong vinegar smell. Talk to your pharmacist about the proper disposal of your medication.
What other information should I know?
Keep all appointments with your doctor.
If you are taking prescription aspirin, do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Hydrocortisone, Neomycin, and Polymyxin (hye droe kor' ti sone) (nee oh mye' sin) (pol i mix' in)

Why is this medication prescribed?
The combination of hydrocortisone, neomycin, and polymyxin eliminates bacteria that cause ear, eye, and skin infections and relieves pain, inflammation, redness, and itching.
How should this medication be used?
This combination of medications comes as eardrops, eye drops, and a topical cream and ointment. The eye drops are usually used every 3 to 4 hours. The eardrops and topical cream and ointment are usually used two to four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use this combination exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Do not use this medication for more than 10 days. If your infection does not improve within 1 week or if it worsens, call your doctor.
To instill the eardrops, follow these directions (to make this procedure easier, have someone else instill the drops):
  1. Wash your hands thoroughly with soap and warm water.
  2. Gently clean your ear with a damp facecloth and then dry your ear.
  3. Warm the drops to near body temperature by holding the container in the palm of your hand for a few minutes.
  4. If the drops are a suspension or if the label indicates, shake the bottle well for 10 seconds.
  5. Check the dropper tip to make sure that it is not chipped or cracked.
  6. Draw the medication into the dropper, or hold the dropper-top bottle with the dropper tip down.
  7. Tilt the affected ear up or lie on your side. Pull the ear backward and upward (or if giving to a child younger than 3 years of age, pull backward and downward) to open the ear canal.
  8. Avoid touching the dropper tip against your ear or anything else; the dropper must be kept clean.
  9. Place the correct number of drops in your ear. Then gently press on the small skin flap (tragus) over the ear to help the drops to run into the ear canal.
  10. Keep your ear tilted up for 5 minutes or insert a soft cotton plug in your ear, whichever method has been recommended by your pharmacist or doctor.
  11. Replace and tighten the cap or dropper right away.
  12. Wash your hands to remove any medication.

To instill the eye drops, follow these steps:
  1. Wash your hands thoroughly with soap and water.
  2. Check the dropper tip to make sure that it is not chipped or cracked.
  3. Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean.
  4. While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.
  5. Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.
  6. Brace the remaining fingers of that hand against your face.
  7. While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.
  8. Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.
  9. Place a finger on the tear duct and apply gentle pressure.
  10. Wipe any excess liquid from your face with a tissue.
  11. If you are to use more than one drop in the same eye, wait at least 5 minutes before instilling the next drop.
  12. Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.
  13. Wash your hands to remove any medication.

To instill the eye ointment follow these directions:
  1. Wash your hands thoroughly with soap and water.
  2. Avoid touching the tip of the tube against your eye or anything else; the tube tip must be kept clean.
  3. Holding the tube between your thumb and forefinger, place it as near to your eyelid as possible without touching it.
  4. Brace the remaining fingers of that hand against your face.
  5. Tilt your head backward slightly.
  6. With your index finger, pull the lower eyelid down to form a pocket.
  7. Squeeze a 1/4- to 1/2-inch (0.6- to 1.25-centimeter) ribbon of ointment or gel into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.
  8. Blink your eye slowly; then gently close your eye for 1 to 2 minutes.
  9. With a tissue, wipe any excess ointment or gel from the eyelids and lashes. With another clean tissue, wipe the tip of the tube clean.
  10. Replace and tighten the cap right away.
  11. Wash your hands to remove any medication.
  12. Your vision may be blurry for a short amount of time after using the eye ointment. Wait until you can see normally before you drive or do other activities that require good vision.

To use the skin cream, wash the affected skin area thoroughly. Then apply a small amount of cream and rub it in gently. If you use the cream on your face, keep it out of your eyes.
When using the cream, do not bandage or otherwise wrap your skin unless directed by your doctor. Do not apply this medication to other areas of the body unless directed by your doctor.
Do not apply cosmetics or other skin preparations to the treated skin area without talking with your doctor.
If you use this medication on a child's diaper area, do not use tight-fitting diapers or plastic pants. Such use may increase side effects.
Your condition should improve within a few days after you start using this medication. Call your doctor if your symptoms do not improve or get worse.
Are there other uses for this medicine?
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
  • AK-Spore HC® Ointment (as a combination product containing Bacitracin, Hydrocortisone, Neomycin, Polymyxin B)
  • AK-Spore HC® Suspension (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Cortatrigen® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Cort-Biotic® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Cortisporin® Ointment (as a combination product containing Bacitracin, Hydrocortisone, Neomycin, Polymyxin B)
  • Cortisporin® Suspension (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Cortomycin® Ointment (as a combination product containing Bacitracin, Hydrocortisone, Neomycin, Polymyxin B)
  • Cortomycin® Suspension (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Drotic® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Ear-Eze® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Lazersporin-C® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Masporin® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Neotricin HC® (as a combination product containing Bacitracin, Hydrocortisone, Neomycin, Polymyxin B)
  • Ocu-Cort® (as a combination product containing Bacitracin, Hydrocortisone, Neomycin, Polymyxin B)
  • Ocutricin HC® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Oticin HC® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Otimar® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Oti-sone® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Otocidin® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Otocort® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)
  • Pediotic® (as a combination product containing Hydrocortisone, Neomycin, Polymyxin B)

What special precautions should I follow?

Before using hydrocortisone, neomycin, and polymyxin,

  • tell your doctor and pharmacist if you are allergic to hydrocortisone, neomycin, polymyxin, or any other drugs.
  • tell your doctor what prescription and nonprescription medications you are taking, especially cancer chemotherapy agents, other topical medications, and vitamins.
  • tell your doctor if you have or have ever had kidney disease, a heart attack, diabetes, glaucoma, cataracts, a perforated eardrum, a circulation disorder, or an immune disorder.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using hydrocortisone, neomycin, and polymyxin, call your doctor immediately.
What side effects can this medication cause?
Hydrocortisone, neomycin, and polymyxin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • itching
  • burning
  • pain
  • swelling
  • drying or cracking of the skin
  • acne
  • change in skin color
  • blurred vision
  • hearing difficulty

If you experience any of the following symptoms, call your doctor immediately:
  • severe skin rash
  • difficulty breathing or swallowing
  • wheezing

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
What should I do if I forget to take a dose?
Instill or apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not instill or apply a double dose to make up for a missed one.
What storage conditions are needed for this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it according to the package instructions. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medications.
What other information should I know?
Keep all appointments with your doctor.
Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Oxycodone (ox i koe' done)

Why is this medication prescribed?
Oxycodone is used to relieve moderate to severe pain. Oxycodone is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.
Oxycodone is also available in combination with acetaminophen (Endocet, Percocet, Roxicet, Tylox, others); aspirin (Endodan, Percodan, Roxiprin, others); and ibuprofen (Combunox). This monograph only includes information about the use of oxycodone alone. If you are taking an oxycodone combination product, be sure to read information about all the ingredients in the product you are taking and ask your doctor or pharmacist for more information.
How should this medication be used?
Oxycodone comes as a solution (liquid), concentrate solution, tablet, capsule, and extended-release (long-acting) tablet to take by mouth. The solution, concentrated solution, tablet, and capsule are usually taken with or without food every 4 to 6 hours, either as needed for pain or as regularly scheduled medications. The extended-release tablet are usually taken every 12 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take oxycodone exactly as directed.
If you are taking the oxycodone concentrate solution, be sure to carefully measure and double check the dose before taking the medication. Use the measuring dropper that comes with the medication to measure your dose. Mix the medication with at least 1 ounce (30 milliliters) of juice or other liquid, or with a semi-solid food such as applesauce or pudding. If you are taking oxycodone concentrate solution from an ampoule (small pre-packaged tube containing oxycodone liquid), be sure to follow your doctor's instructions for taking a dose. Ask your pharmacist or doctor if you have any questions about measuring your dose or taking your medication.
Your doctor will likely start you on a low dose of oxycodone and may increase this dose over time if your pain is not controlled. After you take oxycodone for a period of time, your body may become used to the medication. If this happens, your doctor may need to increase your dose to control your pain. Talk to your doctor about how you are feeling during your treatment with oxycodone.
Oxycodone can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor. If you have been taking oxycodone for more than a few days, do not stop taking oxycodone suddenly. If you stop taking this medication suddenly, you may experience withdrawal symptoms such as restlessness, watery eyes, runny nose, sneezing, yawning, sweating, chills, muscle or joint aches or pains, weakness, irritability, anxiety, depression, difficulty falling asleep or staying asleep, cramps, nausea, vomiting, diarrhea, loss of appetite, fast heartbeat, and fast breathing. Your doctor will probably decrease your dose gradually. Call your doctor if you have any withdrawal symptoms when your dose is decreased or when you stop taking oxycodone.
Ask your doctor or pharmacist for a copy of the manufacturer's information for the patient.
Are there other uses for this medicine?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
  • Combunox® (as a combination product containing Ibuprofen, Oxycodone)
  • Dazidox®
  • Endocet® (as a combination product containing Acetaminophen, Oxycodone)
  • Endocodone®
  • Endodan® (as a combination product containing Aspirin, Oxycodone)
  • ETH-Oxydose®
  • Lynox® (as a combination product containing Acetaminophen, Oxycodone)
  • Magnacet® (as a combination product containing Acetaminophen, Oxycodone)
  • Narvox® (as a combination product containing Acetaminophen, Oxycodone)
  • Oxycontin®
  • Oxyfast®
  • OxyIR®
  • Percocet® (as a combination product containing Acetaminophen, Oxycodone)
  • Percodan® (as a combination product containing Aspirin, Oxycodone)
  • Percolone®
  • Perloxx® (as a combination product containing Acetaminophen, Oxycodone)
  • Primlev® (as a combination product containing Acetaminophen, Oxycodone)
  • Roxicet® (as a combination product containing Acetaminophen, Oxycodone)
  • Roxicodone®
  • Roxiprin® (as a combination product containing Aspirin, Oxycodone)
  • Taxadone® (as a combination product containing Acetaminophen, Oxycodone)
  • Tylox® (as a combination product containing Acetaminophen, Oxycodone)
  • Xolox® (as a combination product containing Acetaminophen, Oxycodone)
What special precautions should I follow?

Before taking oxycodone,

  • tell your doctor and pharmacist if you are allergic to oxycodone, codeine (in many pain relievers and cough medications), hydrocodone (in Hycodan, in Lortab, in Vicoprofen, others),dihydrocodeine (in Synalgos-DC, others), any other medications, or any of the ingredients in oxycodone liquid, tablets, or capsules. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; antihistamines; buprenorphine (Buprenex, Subutex, in Suboxone); butorphanol (Stadol); medications for mental illness, nausea, or seizures; other medications for pain, especially narcotics; muscle relaxants; nalbuphine (Nubain); naloxone (Narcan); nalmefene (Revex); pentazocine (Talwin); sedatives;sleeping pills, or tranquilizers; Also tell your doctor or pharmacist if you are taking the following medications or if you have stopped taking them within the past two weeks: isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had asthma, lung disease, slowed breathing, or paralytic ileus (condition in which digested food does not move through the intestines). Your doctor may tell you not to take oxycodone.
  • tell your doctor if you drink or have ever drunk large amounts of alcohol and if you use or have ever used street drugs, or if you have overused prescription medications. Also tell your doctor if you have or have ever had a head injury,a tumor in your brain or nervous system, any condition causing increased pressure in your brain; hypothyroidism (condition in which the thyroid gland produces less hormone than normal), hallucinations (seeing things or hearing voices that do not exist); delirium tremens (severe withdrawal symptoms that may occur in people who drank large amounts of alcohol over time and have stopped drinking); kyphoscoliosis (curving of the spine that may cause breathing problems) low blood pressure;Addison's disease (condition in which the adrenal gland does not produce enough hormone), seizures; urethral stricture (blockage of the tube that allows urine to leave the body), enlarged prostate (a male reproductive gland), or heart, kidney,liver, or pancreas, or biliary tract disease.
  • tell your doctor if you are pregnant or plan to become pregnant, or are breast-feeding. If you become pregnant while taking oxycodone, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking oxycodone.
  • you should know that this medication may make you drowsy. Do not drive a car, operate heavy machinery, or participate in any other possibly dangerous activities until you know how this medication affects you.
  • ask your doctor about the safe use of alcoholic beverages while you are taking oxycodone. When alcohol is taken with this medication, dangerous side effects can occur.
  • you should know that oxycodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To help avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.


What side effects can this medication cause?
Oxycodone may cause side effects. Tell your doctor if any of these symptoms, are severe or do not go away:
  • nausea
  • vomiting
  • loss of appetite
  • constipation
  • dry mouth
  • lightheadedness
  • drowsiness
  • flushing
  • sweating
  • itching
  • weakness
  • headache
  • mood changes
  • decrease in pupil (dark circle in eye) size
  • red eyes

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
  • fast or slow heartbeat
  • difficulty breathing
  • slowed breathing
  • hives
  • rash
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • hoarseness
  • difficulty swallowing
  • hallucinating (seeing things or hearing voices that do not exist)
  • seizures
  • confusion
  • fainting
  • dizziness
  • loss of consciousness

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Oxycodone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
What should I do if I forget to take a dose?
If you are taking oxycodone on a regular schedule, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What should I do in case of overdose?
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
  • difficulty breathing or slowed or stopped breathing
  • excessive sleepiness
  • dizziness
  • fainting
  • limp or weak muscles
  • increase or decrease in pupil (dark circle in the eye) size
  • cold, clammy skin
  • slow or stopped heartbeat
  • blue color of skin, fingernails, lips, or area around the mouth
  • loss of consciousness or coma

What storage conditions are needed for this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light and excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Throw away oxycodone concentrate solution 90 days after you open the product. Talk to your pharmacist about the proper disposal of your medication.
Keep oxycodone in a safe place so that no one else can take it accidentally or on purpose. Keep track of how much liquid or how many tablets or capsules are left so you will know if any medication is missing.
What other information should I know?
If you are taking the extended-release tablets, you may notice something that looks like a tablet in your stool. This is just the empty tablet shell, and this does not mean that you did not get your complete dose of medication.
Keep all appointments with your doctor.
Do not let anyone else take your medication. Selling or giving away this medication may cause severe harm or death to others and is illegal.
This prescription is not refillable. If you continue to experience pain after you finish the oxycodone, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Important warning
Oxycodone extended-release (long-acting) tablets should be used only to treat people who need regularly scheduled doses of pain medication to treat continuous pain for an extended period of time. Extended-release oxycodone tablets should not be taken as-needed or to treat occasional episodes of pain.
Oxycodone 60-mg tablets and oxycodone 160-mg tablets (not available in the United States) should only be used to treat people who are tolerant (used to the effects of a medication) to narcotic pain medication. These tablet strengths may cause serious breathing problems or death in people who are not tolerant to narcotics.
Swallow oxycodone extended-release tablets whole; do not chew, break, divide, crush, or dissolve them. If you swallow broken, chewed, or crushed extended-release tablets, you will receive the entire dose of oxycodone at once, instead of slowly over 12 hours. This may cause serious problems, including overdose and death.
Talk to your doctor about the risks of taking oxycodone.
Notification
[Posted 01/13/2011] ISSUE: FDA notified healthcare professionals that it has asked drug manufacturers to limit the strength of acetaminophen in prescription drug products, predominantly combinations of acetaminophen and opioids, to 325 mg per tablet, capsule, or other dosage unit, making these products safer for patients. This action will help to reduce the risk of severe liver injury and allergic reactions associated with acetaminophen. A Boxed Warning highlighting the potential for severe liver injury and a Warning highlighting the potential for allergic reactions (swelling of the face, mouth, and throat, difficulty breathing, itching, or rash) will be added to the label of all prescription drug products that contain acetaminophen.
BACKGROUND: Acetaminophen, one of the most commonly used drugs in the United States, is widely and effectively used in both prescription and over-the-counter (OTC) products to reduce pain and fever. Examples of prescription products that contain acetaminophen include hydrocodone with acetaminophen (Vicodin, Lortab), and oxycodone with acetaminophen (Tylox, Percocet). OTC products containing acetaminophen (e.g., Tylenol) are not affected by this action. Information about the potential for liver injury is already required on the label for OTC products containing acetaminophen. FDA is continuing to evaluate ways to reduce the risk of acetaminophen related liver injury from OTC products. No drug shortages are expected, because the 3-year implementation period should permit adequate time for necessary reformulations.
RECOMMENDATION: Healthcare professionals were reminded to advise patients not to exceed the acetaminophen maximum total daily dose (4 grams/day), and not to drink alcohol while taking acetaminophen-containing medications.
Healthcare professionals were encouraged to inform patients that there is no immediate danger to patients who take these combination pain medications, and patients should continue to take them as directed by their health care provider. The Drug Safety Communication provides additional information for healthcare professionals, information for patients, a data summary and a list of all affected products. For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety.